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KMID : 0377619760300020201
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Korean Jungang Medical Journal
1976 Volume.30 No. 2 p.201 ~ p.205
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Studies on the Drug-Induced Hemolytic Anemia and X Chromosomal Inactivation in G-6-PD Deficiency
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高光三/Koh, Kwang Sam
梁南吉/朴順化/車種希/Yang, Nam Gil/Park, Soon Wha/Chong, Hee Cha
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Abstract
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Glucose 6 phosphate dehydrogenase (G-6-PD) deficiency was found to be the main genetic cause for the participation of acute hemolysis.
Since the gene determining the structure of G-6-PD molecule is located on the X chromosome, the ingestion of certain drugs can be induce the X chromosomal inactivation.
In this study, an attempt has been made to investigate the drug-induced hemolytic anemia, erythrocyte G-6-PD deficiency and X chromosomal inactivation ;after the ingestion of certain drugs in vivo.
The ingestion of quinine, primaguine and methylene blue has been induced the severe decreased hemoglobin and erythrocyte G-6-PD values, the recovery of these decreased values was not achieved.
And acetylsalicylic acid, sulfadimethoxine and ascorbic acid has been induced -the decreased hemoglobin value and erythrocyte G-6-PD activity, but the recovery was slightly achieved.
The effect of the ingestion of chloramphenicol, menadione and diphenhydram￢ine on the hemoglobin value and erythrocyte G-6-PD activity were slightly decreased, and the recovery was achieved.
And sodium nitrite has been not affected to the hemoglobin value and eryth￢rocyte G-6-PD activity.
The X chromosomal inactivation was not induced by the ingestion of these drugs which was prolonged for 30 days.
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